The book is logically divided to cover basic science and the dermatologic systemic and psychiatric aspects of itch as well as therapy while there are no weak chapters several are outstanding andrew carmichael and c n ghent discuss uremic and cholestatic pruritus respectively in a logical detail i had not previously encountered jeffrey shornick incorporates his extensive knowledge of . Itch mechanisms and management of pruritus paperback october 23 1994 by jeffrey d bernhard author visit amazons jeffrey d bernhard page find all the books read about the author and more see search results for this author are you an author learn about author central jeffrey d bernhard author see all formats and editions hide other formats and editions price new from . Pruritus itch is a common complication of cholestatic liver diseases cld it can be a distressing and debilitating symptom causing significant impairment in quality of life treatment of pruritus in liver diseases can be challenging and requires specific management with early initiation and a step wise approach using specific drugs. The management of pruritus associated with pbc is described by the 2009 american association for the study of liver diseases aasld guidelines 42 and involves use of bile salt resins as first line therapy rifampin 150 300 mg twice daily as second line opiod antagonists eg naltrexone up to 50 mg daily as third line therapy and sertraline 75 100 mg day as fourth line therapy followed by experimental approaches
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